Lafutidine is chemically 2-[(2-furylmethyl) sulfinyl]-N-((2Z)-4-{[4- (piperidin-1- ylmethyl) pyridin-2-yl] oxy}but-2-en-1- yl) acetamide1 is used in the treatment of ulcer. Antisecretory drugs are used in the treatment and prophylaxis of peptic ulcer disease some are also employed in other disorders associated with gastric hyperacidity such as gastro-oesophageal reflux disease and dyspepsia. As Lafutidine is not official in any pharmacopoeia, no official analytical method is there for estimation of this drug. Literature survey reveals few analytical methods like liquid chromatography, stability indicating HPLC, colorimetric and biological assay are reported; there was no mention of a method based on spectrophotometric estimation. The present work describes a validated first order derivative Spectrophotometric method measurement for estimation of Lafutidine. The present work describes a validated first derivative Spectrophotometric method for estimation of Lafutidine in bulk and in tablet formulation. The solvent used was methanol for parent dilution and then sodium hydroxide for further dilution. Absorbance a minimum in first order derivative spectra was found at 284 nm, the drug followed a linear relationship in the range of 10-35μg/ml while the correlation coefficient was found 0.996. The recovery was 99.89% and the coefficient of variance for intraday and interday was found to be less than 5%, LOD and LOQ for this method was found 10 μg/ml and 35 μg/ml respectively. The proposed UV- Visible spectrophotometric method is a simple, specific, rapid, accurate, economic and found suitable for day to day analysis of lafutidine in bulk and its formulation.
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